Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury

Induction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor

Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...

Heme Oxygenase-1 and Acute Kidney Injury following Cardiac Surgery.

BACKGROUND Intraoperative hemolysis and inflammation are associated with acute kidney injury (AKI) following cardiac surgery. Plasma-free hemoglobin induces heme oxygenase-1 (HO-1) expression. HO-1 degrades heme but increases in experimental models of AKI. This study tested the hypothesis that plasma HO-1 concentrations are associated with intraoperative hemolysis and are increased in patients ...

Heme Proteins, Heme Oxygenase-1 and Oxidative Stress

Heme is ferrous protoporphyrin-IX that is the prosthetic group of hemoproteins, such as hemoglobin, myoglobin and cytochromes that are of vital importance. In contrast, “free heme”, a protein-unbound heme, that is either just synthesized but yet not incorporated into hemoproteins, or that is released from hemoprotein under oxidative conditions, is highly toxic, since it catalyzes the production...

Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock

Hemorrhagic shock causes oxidative stress that leads to tissue injuries in various organs including the lung, liver, kidney and intestine. Excess amounts of free heme released from destabilized hemoproteins under oxidative conditions might constitute a major threat because it can catalyze the formation of reactive oxygen species. Cells counteract this by rapidly inducing the rate-limiting enzym...

Heme Oxygenase-1 Mediated Cytoprotection in Acute Lung Injury